Jul 6, 2021
Correlative chemical imaging in symbiosis: Our workflow, combining mass spectrometry imaging and microCT in a multimodal 3D atlas of a symbiotic invertebrate is now online in PNAS. Congrats Benedikt!
We use modern mass-spectrometry methods to understand which molecules are involved in marine host-microbe systems, how different metabolites shape ecological communities, and how the symbiotic partners respond metabolically to environmental changes.
The research in this lab is constantly driven by method developments like high-resolution mass-spectrometry imaging to reveal the spatial metabolome of microbial systems. Our expertise is microbial metabolomics with a special focus on marine systems.
The mass2adduct paper, which describes a method for identifying adducts in mass-spec imaging data, was recently published. Congrats to the team consisting of Moritz Janda, Brandon KB Seah, Dennis Jakob, Janine Beckmann, Benedikt Geier, and Manuel Liebeke. Find out more at these links:
Dennis Jakob presented a poster at the virtual It Ma(t)Ters conference on his Master's thesis work combining spatial metabolomics with spatial transcriptomics. With this work, Dennis won one of the poster prizes voted on by the conference attendees.
The Otto Mønsted Foundation has provided funding for Dr. Manuel Liebeke to join as a guest professor at the Danish Technical Institute in 2021. He will collaborate with the CeMiSt center in their new mass spectrometry imaging center and participate in talks, seminars, and other interactions with ...
|Michellod D, Bien T, Birgel D, Violette M, Kleiner M, Fearn S, Zeidler C, Gruber-Vodicka HR, Dubilier N, Liebeke M. 2023. De novo phytosterol synthesis in animals. Science
|Geier B, Oetjen J, Ruth Steiner B, Polikarpov M, Gruber-Vodicka HR, Liebeke M. 2021. Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. PNAS. 118 (27) e2023773118; 10.1073 / pnas.2023773118|
|Janda M, Seah BKB, Jakob D, Beckmann J, Geier B, and Liebeke M. 2021. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets. Analytical Chemistry. 93 (24): 8399-8407. 10.1021 / acs.analchem.0c04720|
|Geier, B., Sogin, E., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N. & Liebeke M. 2020. Spatial metabolomics of in situ host - microbe interactions at the micrometer scale. Nature Microbiology. doi.org/10.1038/s41564-019-0664-6|
|Sogin EM, Puskás E, Dubilier N, Liebeke M. 2019. Marine Metabolomics: a method for nontargeted measurement of metabolites in seawater by gas chromatography - mass spectrometry. mSystems 4 (6): e00638-19. 10.1128 / mSystems.00638-19|