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Research Group Metabolic Interactions

We use modern mass-spectrometry methods to understand which molecules are involved in marine host-microbe systems, how different metabolites shape ecological communities, and how the symbiotic partners respond metabolically to environmental changes.

The research in this lab is constantly driven by method developments like high-resolution mass-spectrometry imaging to reveal the spatial metabolome of microbial systems. Our expertise is microbial metabolomics with a special focus on marine systems.

Top Left © Aman Akeerath Mundanatt; Top Right © MARUM; Bottom © HYDRA Institute

Latest News

Showing 11-15 of 19 items.

mass2adduct paper published in Analytical Chemistry

Jun 7, 2021

The mass2adduct paper, which describes a method for identifying adducts in mass-spec imaging data, was recently published. Congrats to the team consisting of Moritz Janda, Brandon KB Seah, Dennis Jakob, Janine Beckmann, Benedikt Geier, and Manuel Liebeke. Find out more at these links:

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Poster prize at the It Ma(t)Ters conference

Apr 14, 2021

Dennis Jakob presented a poster at the virtual It Ma(t)Ters conference on his Master's thesis work combining spatial metabolomics with spatial transcriptomics. With this work, Dennis won one of the poster prizes voted on by the conference attendees. 

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Dennis Jakob defended his Master's thesis

Mar 23, 2021

We congratulate Dennis Jakob, who successfully defended his Master's thesis entitled, "Combining MALDI MS imaging and transcriptomics to investigate phenotypic heterogeneity of intracellular symbionts in deep-sea mussels" 

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Select Publications

Michellod D, Bien T, Birgel D, Violette M, Kleiner M, Fearn S, Zeidler C, Gruber-Vodicka HR, Dubilier N, Liebeke M. 2023. De novo phytosterol synthesis in animals. Science
Geier BOetjen JRuth Steiner BPolikarpov M, Gruber-Vodicka HR, Liebeke M2021. Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. PNAS. 118 (27) e2023773118; 10.1073 / pnas.2023773118
Janda M, Seah BKB, Jakob D, Beckmann J, Geier B, and Liebeke M. 2021. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets. Analytical Chemistry. 93 (24): 8399-8407. 10.1021 / acs.analchem.0c04720 
Geier, B., Sogin, E., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N. & Liebeke M. 2020. Spatial metabolomics of in situ host - microbe interactions at the micrometer scale. Nature Microbiology.
Sogin EM, Puskás E, Dubilier N, Liebeke M. 2019. Marine Metabolomics: a method for nontargeted measurement of metabolites in seawater by gas chromatography - mass spectrometry. mSystems 4 (6): e00638-19. 10.1128 / mSystems.00638-19
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