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Research Group Metabolic Interactions

Our lab studies metabolic interactions between microbes and marine organisms living in symbiosis. We are using modern mass-spectrometry methods to understand which molecules are involved in host-microbe systems, how different metabolites shape the community and also how the symbiotic partner respond metabolically to environmental changes.

The research in his lab is constantly driven by method developments like high-resolution mass-spectrometry imaging to reveal the spatial metabolome of microbial systems. Our expertise is microbial metabolomics with a special focus on marine systems.

Research Group Metabolic Interactions 2021
Research Group Metabolic Interactions 2021

Group leader

Dr. Manuel Liebeke

MPI for Marine Microbiology
Celsiusstr. 1
D-28359 Bremen




+49 421 2028-8220

Dr. Manuel Liebeke

Latest News

Showing 1-5 of 12 items.

Sea4Society Project is Underway

Aug 27, 2021

De­vel­op­ing in­nov­at­ive and so­cially ac­cep­ted ap­proaches to im­prove the nat­ural po­ten­tial for car­bon stor­age in ve­get­a­tion-rich coastal eco­sys­tems: that is the goal of the new re­search con­sor­tiumsea4soCiety, in which the Max Planck In­sti­tute for Mar­ine Mi­cro­bi­o­logy in...

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New AP-SMALDI-5AF laser ion source installed

Jul 23, 2021

A new laser ion source was installed in our lab. With the brand new AP-SMALDI-5AF we are able to do routine measurements at spatial resolution down to 5 µm. Additionally we increase measurement speed and sample throughput up to ten fold if a lower mass resolution is acceptable. 


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mass2adduct paper published in Analytical Chemistry

Jun 7, 2021

The mass2adduct paper, which describes a method for identifying adducts in mass-spec imaging data, was recently published. Congrats to the team consisting of Moritz Janda, Brandon KB Seah, Dennis Jakob, Janine Beckmann, Benedikt Geier, and Manuel Liebeke. Find out more at these links:

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Select Publications

Geier BOetjen JRuth Steiner BPolikarpov M, Gruber-Vodicka HR, Liebeke M2021. Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. PNAS. 118 (27) e2023773118; 10.1073 / pnas.2023773118
Janda M, Seah BKB, Jakob D, Beckmann J, Geier B, and Liebeke M. 2021. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets. Analytical Chemistry. 93 (24): 8399-8407. 10.1021 / acs.analchem.0c04720 
Geier, B., Sogin, E., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N. & Liebeke M. 2020. Spatial metabolomics of in situ host - microbe interactions at the micrometer scale. Nature Microbiology.
Sogin EM, Puskás E, Dubilier N, Liebeke M. 2019. Marine Metabolomics: a method for nontargeted measurement of metabolites in seawater by gas chromatography - mass spectrometry. mSystems 4 (6): e00638-19. 10.1128 / mSystems.00638-19
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