Forschungsgruppe Metabolische Interaktionen

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Our lab studies metabolic interactions between microbes and marine organisms living in symbiosis. We are using modern mass-spectrometry methods to understand which molecules are involved in host-microbe systems, how different metabolites shape the community and also how the symbiotic partner respond metabolically to environmental changes.

The research in his lab is constantly driven by method developments like high-resolution mass-spectrometry imaging to reveal the spatial metabolome of microbial systems. Our expertise is microbial metabolomics with a special focus on marine systems.

Research Group Metabolic Interactions 2021
Research Group Metabolic Interactions 2021


Dr. Manuel Liebeke

MPI for Marine Microbiology
Celsiusstr. 1
D-28359 Bremen




+49 421 2028-8220

Dr. Manuel Liebeke

Latest News

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Poster prize at the It Ma(t)Ters conference


Dennis Jakob presented a poster at the virtual It Ma(t)Ters conference and on his Master's thesis work combining spatial metabolomics with spatial transcriptomics. With this work, Dennis won the prize for best poster voted on by the conference attendees.

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Dennis Jakob Master's Thesis Defence



We congratulate Dennis Jakob, who successfully defended his Master's thesis entitled, "Combining MALDI MS imaging and transcriptomics to investigate phenotypic heterogeneity of intracellular symbionts in deep-sea mussels" 

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Select Publications

Geier BOetjen JRuth Steiner BPolikarpov M, Gruber-Vodicka HR, Liebeke M2021. Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. PNAS. 118 (27) e2023773118; 10.1073 / pnas.2023773118
Janda M, Seah BKB, Jakob D, Beckmann J, Geier B, and Liebeke M. 2021. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets. Analytical Chemistry. 93 (24): 8399-8407. 10.1021 / acs.analchem.0c04720 
Geier, B., Sogin, E., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N. & Liebeke M. 2020. Spatial metabolomics of in situ host - microbe interactions at the micrometer scale. Nature Microbiology.
Sogin EM, Puskás E, Dubilier N, Liebeke M. 2019. Marine Metabolomics: a method for nontargeted measurement of metabolites in seawater by gas chromatography - mass spectrometry. mSystems 4 (6): e00638-19. 10.1128 / mSystems.00638-19
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